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Beta blockers, due to their antagonism at beta-1 adrenergic receptors, inhibit both the synthesis of new melatonin and its secretion by the pineal gland. The neuropsychiatric side effects of some beta blockers (e.g. sleep disruption, insomnia ) may be due to this effect.
Selective beta 2 blockers impede the activity of beta 2 adrenergic receptors that are mainly situated in the airway smooth muscle of the lungs. [5] By inhibiting the beta 2 receptor-mediated smooth muscle relaxation, beta 2 blockers narrow airways and blood vessels. [5]
The combination of beta blockers and antihypertensive drugs will work on different mechanism to lower blood pressure. [17] For example, the co-administration of beta-1 blocker atenolol and ACE inhibitor lisinopril could produce a 50% larger reduction in blood pressure than using either drug alone. [18]
Pages in category "Beta blockers" ... Template:Beta blockers; Beta-2 adrenergic antagonist; Beta-3 adrenergic antagonist; Betaxolol; Bevantolol; Bimatoprost/timolol;
An adrenergic antagonist is a drug that inhibits the function of adrenergic receptors. There are five adrenergic receptors, which are divided into two groups. The first group of receptors are the beta (β) adrenergic receptors. There are β 1, β 2, and β 3 receptors. The second group contains the alpha (α) adrenoreceptors.
Figure 1: The chemical structure of dichloroisoprenaline or dichloroisoproterenol (), abbreviated DCI — the first β-blocker to be developed. β adrenergic receptor antagonists (also called beta-blockers or β-blockers) were initially developed in the 1960s, for the treatment of angina pectoris but are now also used for hypertension, congestive heart failure and certain arrhythmias. [1]