Ad
related to: what does azacitidine do for humans- Dosing With INQOVI
Oral Dosing Schedule & What To Do
If Modifications Are Needed.
- Patient Considerations
Learn Which Patients May
Be Appropriate For INQOVI.
- INQOVI Efficacy & Safety
Learn About Trial Results
Including Safety & Efficacy.
- INQOVI HCP Resources
Download Helpful Resources For
HCPs Treating With INQOVI.
- Dosing With INQOVI
Search results
Results From The WOW.Com Content Network
Azacitidine is a chemical analogue of the nucleoside cytidine, which is present in DNA and RNA.It is thought to have antineoplastic activity via two mechanisms – at low doses, by inhibiting of DNA methyltransferase, causing hypomethylation of DNA, [16] and at high doses, by its direct cytotoxicity to abnormal hematopoietic cells in the bone marrow through its incorporation into DNA and RNA ...
Azacitidine and decitabine are marketed as Vidaza and Dacogen respectively. Azacitidine is the first drug to be approved by FDA for treating MDS and has been given orphan drug status. [2] [3] Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. [4]
A hypomethylating agent (or demethylating agent [1]) is a drug that inhibits DNA methylation: the modification of DNA nucleotides by addition of a methyl group.Because DNA methylation affects cellular function through successive generations of cells without changing the underlying DNA sequence, treatment with a hypomethylating agent is considered a type of epigenetic therapy.
Venetoclax is also indicated as part of a combination therapy for acute myeloid leukemia (AML). [7] For this purpose it is used with azacitidine, decitabine, or low-dose cytarabine for newly diagnosed adults who are age 75 years or older, or those with other health problems where intensive chemotherapy cannot be used.
A variety of cytidine analogues are known, some with potentially useful pharmacology. For example, KP-1461 is an anti-HIV agent that works as a viral mutagen, [5] and zebularine exists in E. coli and is being examined for chemotherapy.
Decitabine is a hypomethylating agent. [7] [8] It hypomethylates DNA by inhibiting DNA methyltransferase.It functions in a similar manner to azacitidine, although decitabine can only be incorporated into DNA strands while azacitidine can be incorporated into both DNA and RNA chains.
Obecabtagene autoleucel, sold under the brand name Aucatzyl, is an anti-cancer medication used for the treatment of acute lymphoblastic leukemia. [1] [2] It is a CD19-directed genetically modified autologous T-cell immunotherapy.
Vincristine is delivered via intravenous infusion for use in various types of chemotherapy regimens. [3] Its main uses are in non-Hodgkin's lymphoma as part of the chemotherapy regimen CHOP R-CVP, Hodgkin's lymphoma as part of MOPP, COPP, BEACOPP, or the less popular Stanford V chemotherapy regimen in acute lymphoblastic leukemia (ALL), and in treatment for nephroblastoma as well as the ...