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IgG4-related disease (IgG4-RD), formerly known as IgG4-related systemic disease, is a chronic inflammatory condition characterized by tissue infiltration with lymphocytes and IgG4-secreting plasma cells, various degrees of fibrosis (scarring) and a usually prompt response to oral steroids.
Symptoms typically begin 12–48 hours after the triggering activity, [5] but may be immediate, or delayed up to 7 days. [6] PEM lasts "usually a day or longer", [9] but can span hours, days, weeks, or months. [6] [11] PEM involves an exacerbation of symptoms, or the appearance of new symptoms, which are often severe enough to impact a person's ...
This includes other types of inflammatory arthritis like RA, psoriatic arthritis, and septic arthritis. Gout can also appear similar to another condition called calcium pyrophosphate deposition ...
These symptoms may persist or occur periodically and if symptoms are not managed, major complications may develop including permanent joint changes, chronic pain, and functional disabilities. [7] Ultimately, antiarthritic treatments aim to achieve disease remission or low disease activity if remission cannot be achieved and thereby improving ...
It may also be accompanied by arthritis (more prominent in men) and fever. The arthritis is often acute and involves the lower extremities, particularly the ankles. [2] Löfgren syndrome consists of the triad of erythema nodosum, bilateral hilar lymphadenopathy on chest radiograph, and joint pain. [citation needed]
[1] [2] Specifically, arthralgia is a symptom of injury, infection, illness (in particular arthritis), or an allergic reaction to medication. [ 3 ] According to MeSH , the term arthralgia should only be used when the condition is non-inflammatory, and the term arthritis should be used when the condition is inflammatory .