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ROC curve of three predictors of peptide cleaving in the proteasome. A receiver operating characteristic curve, or ROC curve, is a graphical plot that illustrates the performance of a binary classifier model (can be used for multi class classification as well) at varying threshold values.
An image of different ROC curves is shown in Figure 1. ROC curves provide a simple visual method for one to determine the boundary limit (or the separation threshold) of a biomarker or a combination of biomarkers for the optimal combination of sensitivity and specificity. The AUC (area under the curve) of the ROC curve reflects the overall ...
The Partial Area Under the ROC Curve (pAUC) is a metric for the performance of binary classifier. It is computed based on the receiver operating characteristic (ROC) curve that illustrates the diagnostic ability of a given binary classifier system as its discrimination threshold is varied.
The receiver operating characteristic (ROC) also characterizes diagnostic ability, although ROC reveals less information than the TOC. For each threshold, ROC reveals two ratios, hits/(hits + misses) and false alarms/(false alarms + correct rejections), while TOC shows the total information in the contingency table for each threshold. [ 2 ]
Receiver Operating Characteristic (ROC) curve with False Positive Rate and True Positive Rate. A diagonal shows the performance of a random classifier. 3 curved lines from 0,0 to 1,1 that get progressively closer to 0,1 show improving classifiers.
The relationship between sensitivity and specificity, as well as the performance of the classifier, can be visualized and studied using the Receiver Operating Characteristic (ROC) curve. In theory, sensitivity and specificity are independent in the sense that it is possible to achieve 100% in both (such as in the red/blue ball example given above).
The output is called a CAP curve. [1] The CAP is distinct from the receiver operating characteristic (ROC) curve, which plots the true-positive rate against the false-positive rate. CAPs are used in robustness evaluations of classification models.
Youden's index is often used in conjunction with receiver operating characteristic (ROC) analysis. [4] The index is defined for all points of an ROC curve, and the maximum value of the index may be used as a criterion for selecting the optimum cut-off point when a diagnostic test gives a numeric rather than a dichotomous result.