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Glioblastoma, previously known as glioblastoma multiforme (GBM), is the most aggressive and most common type of cancer that originates in the brain, and has a very poor prognosis for survival. [ 6 ] [ 7 ] [ 8 ] Initial signs and symptoms of glioblastoma are nonspecific. [ 1 ]
The giant-cell glioblastoma is a histological variant of glioblastoma, presenting a prevalence of bizarre, multinucleated (more than 20 nuclei) giant (up to 400 μm diameter) cells. It occasionally shows an abundant stromal reticulin network and presents a high frequency of TP53 gene mutations .
Temozolomide is an alkylating agent used to treat serious brain cancers; most commonly as second-line treatments for astrocytoma and as the first-line treatment for glioblastoma. [ 4 ] [ 6 ] [ 7 ] Olaparib in combination with temozolomide demonstrated substantial clinical activity in relapsed small cell lung cancer . [ 8 ]
John McCain suffers from a highly malignant form of cancer that spreads quickly due to its association with a large network of blood vessels in the brain.
Glioblastoma multiforme 1 year [200] Ted Kennedy: 1932–2009 United States Senator from Massachusetts Glioblastoma multiforme 15 months [201] Peter Law: 1948–2006 Welsh politician, independent Member of Parliament (MP) and AM. — —
Neuro-oncology is the study of brain and spinal cord neoplasms, many of which are (at least eventually) very dangerous and life-threatening (astrocytoma, glioma, glioblastoma multiforme, ependymoma, pontine glioma, and brain stem tumors are among the many examples of these).
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