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Fenticonazole is an imidazole antifungal drug, used locally as the nitrate in the treatment of vulvovaginal candidiasis. It is active against a range of organisms including dermatophyte pathogens, Malassezia furfur, and Candida albicans.
The prevention of Candida infections in people with weak immune systems, such as those neutropenic due to cancer chemotherapy, those with advanced HIV infections, transplant patients, and premature infants. As a second-line agent for the treatment of cryptococcal meningoencephalitis, a fungal infection of the central nervous system.
It is active against some fungi including Candida albicans. Candicidin is administered intravaginally in the treatment of vulvovaginal candidiasis. [1] This bioactive compound was named candicidin, because of its high activity on Candida albicans. [2]
Invasive candidiasis is an infection (candidiasis) that can be caused by various species of Candida yeast. Unlike Candida infections of the mouth and throat (oral candidiasis) or vagina (Candidal vulvovaginitis), invasive candidiasis is a serious, progressive, and potentially fatal infection that can affect the blood (), heart, brain, eyes, bones, and other parts of the body.
It is used to treat Candida infections of the skin including diaper rash, thrush, esophageal candidiasis, and vaginal yeast infections. [1] It may also be used to prevent candidiasis in those who are at high risk. [1] Nystatin may be used by mouth, in the vagina, or applied to the skin. [1]
Clotrimazole is usually used five times daily for 14 days for oral thrush, twice daily for 2 to 8 weeks for skin infections, and once daily for 3 or 7 days for vaginal infections. [ 10 ] Clotrimazole may be compounded with a glucocorticoid , such as betamethasone , in a topical cream for the treatment of tinea corporis (ringworm), tinea cruris ...
Broad range (especially against all Candida), thus can be given empirically in febrile neutropenia and stem cell transplant; Can be used in case of azole-resistant Candida or use as a second-line agent for refractory aspergillosis; Long half-life (polyphasic elimination: alpha phase 1–2 hours + beta phase 9–11 hours + gamma phase 40–50 hours)
This study focused on the drug as an 80 mg vaginal suppository, taken three times overnight by 10 women. [4] In another placebo-controlled, double blind study by Schmidt et al., the efficacy of different concentrations of terconazole creams were tested. Cream was applied for three days to 24 women between the ages of 18 and 60.