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A leprostatic agent is a drug that interferes with proliferation of the bacterium that causes leprosy. [1] [2] The following agents are leprostatic agents: [3] acedapsone; clofazimine; dapsone; desoxyfructo-serotonin; diucifon; ethionamide; rifampicin; rifapentine; sulfameter; thalidomide; Leprosy is a chronic infectious disease caused by ...
Leprosy, sometimes known as Hansen's disease, is an infectious disease caused by Mycobacterium leprae, an aerobic, acid-fast, rod-shaped mycobacterium. The modern term for the disease is named after the discoverer of the bacterium, Gerhard Armauer Hansen .
Leprosy has historically been associated with social stigma, which continues to be a barrier to self-reporting and early treatment. [4] Leprosy is classified as a neglected tropical disease. [21] World Leprosy Day was started in 1954 to draw awareness to those affected by leprosy. [22] [4] The study of leprosy and its treatment is known as ...
Mycobacterium leprae (also known as the leprosy bacillus or Hansen's bacillus) is one [a] of the two species of bacteria that cause Hansen's disease (leprosy), [1] a chronic but curable infectious disease that damages the peripheral nerves and targets the skin, eyes, nose, and muscles.
Mycobacterium leprae, the causative agent of leprosy, was discovered by G. H. Armauer Hansen in Norway in 1873, making it the first bacterium to be identified as causing disease in humans. [2] [25] Hansen observed a number of nonrefractile small rods in unstained tissue sections. The rods were not soluble in potassium lye, and they were acid ...
Hansen remained medical officer for leprosy in Norway and it was through his efforts that the leprosy acts of 1877 and 1885 were passed, leading to a steady decline of the disease in Norway from 1,800 known cases in 1875 to just 575 cases in 1901. Hansen had had syphilis since the 1860s but died of heart disease. He was an atheist. [10] [11]
They concluded that a single dose of a combination of rifampicin, ofloxacin and minocycline is an acceptable and cost-effective alternative regimen for the treatment of single-lesion paucibacillary leprosy and the duration of the standard regimen for multibacillary leprosy could be shortened to 12 months.
Aldo Castellani was the first to prepare a substance similar to lepromin while attempting to produce a leprosy vaccine. [6] [7] Kensuke Mitsuda worked with lepromin starting in 1916 and published the first paper on it in 1919 [8] However, he retained Ernest Reinhold Rost's earlier name leprolin and his original idea was to find a test that distinguishes leprosy patients from non-leprosy persons.