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Liquid metformin is typically taken with meals once or twice a day. The same advice goes here, too: If you take metformin twice or three times a day, aim to take it at the same times each day.
If metformin is causing GI side effects such as diarrhea or bloating, first try reducing the dose and taking it just once a day instead of twice a day, Dr. Gupta suggests.
Metformin is usually started as 500 to 1000 mg tablets twice a day by mouth (PO), usually with meals. [34] If taking the extended release tablets, they should be always swallowed whole as cutting the tablet will cause faster release of the medication. [ 34 ]
For extended-release tablets for diabetes, a healthcare professional may prescribe a starting dose of 500mg of metformin once a day. This dose may then increase by 500mg each week, up to a maximum ...
[76] [81] The discomfort can often be avoided by beginning at a low dose (1.0 to 1.7 g/day) and increasing the dose gradually, but even with low doses, 5% of people may be unable to tolerate metformin. [76] [82] Use of slow or extended-release preparations may improve tolerability. [82]
At the 8th week itself, PPBG needs to be estimated because, in case PPBG is > 110 mg/dl at this week, a grace period of 2 weeks is available to bring it down to PPBG <110 mg/dl at the 10th week with metformin 250 mg twice a day, in addition to Medical Nutritional Therapy (MNT) and exercise. [13]