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It has been thought that if someone is deficient in vitamin B 12 and folic acid, the vitamin B 12 deficiency must be treated first. However, the basis for this has been challenged, although due to ethical considerations it is no longer able to be tested if "neuropathy is made more severe as a result of giving folic acid to vitamin B 12 ...
Vitamin B 12 deficiency can be determined, but not always. [14] This means it measures forms of vitamin B 12 that are "active" and can be used by the body, as well as the "inactive" forms, which cannot. [150] Vitamin B 12 deficiency can be found within normal levels, so clinical symptoms should be taken into account when a diagnosis is made. [2]
Peripheral neuropathy may be classified according to the number and distribution of nerves affected (mononeuropathy, mononeuritis multiplex, or polyneuropathy), the type of nerve fiber predominantly affected (motor, sensory, autonomic), or the process affecting the nerves; e.g., inflammation (), compression (compression neuropathy), chemotherapy (chemotherapy-induced peripheral neuropathy).
The efficacy of methylcobalamin administration in treating vitamin B12 deficiency remains uncertain. While directly providing active cobalamin forms to deficient patients is an attractive approach promoted by the manufacturers of methylcobalamin products, it is not known whether methylcobalamin can reach its intracellular targets in its ...
Other symptoms of vitamin B12 deficiency include memory loss, fatigue and weakness, nerve damage causing numbness and tingling in the arms and legs, dementia, depression, and seizures.
“Vitamin B12 is an essential water-soluble vitamin that plays a critical role in helping the brain and nervous system function,” says Ashley Kitchens, RDN, of Plant Centered Nutrition. “It ...