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The general chemical structure of bisphosphonate. The R-groups determine the chemical properties of the drug, and distinguishes individual types of bisphosphonates. This chemical structure affords a high affinity for calcium hydroxyapatite, allowing for rapid and specific skeletal targeting. Bisphosphonates are a class of drugs that prevent the ...
Chemical structure of bisphosphonates. Bisphosphonates are an important class of drugs originally commercialised in the mid to late 20th century. They are used for the treatment of osteoporosis and other bone disorders that cause bone fragility and diseases where bone resorption is excessive.
Bisphosphonates are popular drugs for treatment of osteoporosis. [1] Clodronic acid is a bisphosphonate used as a drug to treat osteoporosis. In biochemistry and medicinal chemistry, phosphonate groups are used as stable bioisosteres for phosphate, such as in the antiviral nucleotide analog, Tenofovir, one of the cornerstones of anti-HIV therapy.
Etidronic acid is a bisphosphonate used to strengthen bone, treat osteoporosis, and treat Paget's disease of bone. Bisphosphonates primarily reduce osteoclastic activity, which prevents bone resorption , and thus moves the bone resorption/formation equilibrium toward the formation side and hence makes bone stronger on the long run.
Medronic acid (conjugate base, medronate), also known as methylene diphosphonate, is the smallest bisphosphonate. Its complex with radioactive technetium , 99m Tc medronic acid , is used in nuclear medicine to detect bone abnormalities, including metastases .
Pages in category "Bisphosphonates" The following 17 pages are in this category, out of 17 total. This list may not reflect recent changes. ...
Properties Chemical formula. C 9 H 12 N 2 O 7 P 2: Molar mass: 322.150 g·mol −1 ... Minodronic acid is a third-generation bisphosphonate drug.
Ibandronic acid is a bisphosphonate medication used in the prevention and treatment of osteoporosis and metastasis-associated skeletal fractures in people with cancer. [4] It may also be used to treat hypercalcemia (elevated blood calcium levels). It is typically formulated as its sodium salt ibandronate sodium. [medical citation needed]