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Signs of hyperestrogenism may include heightened levels of one or more of the estrogen sex hormones (usually estradiol and/or estrone), lowered levels of follicle-stimulating hormone and/or luteinizing hormone (due to suppression of the hypothalamic–pituitary–gonadal axis by estrogen), and lowered levels of androgens such as testosterone (generally only relevant to males). [1]
Aromatase excess syndrome (AES or AEXS) is a rarely diagnosed genetic and endocrine syndrome which is characterized by an overexpression of aromatase, the enzyme responsible for the biosynthesis of the estrogen sex hormones from the androgens, in turn resulting in excessive levels of circulating estrogens and, accordingly, symptoms of hyperestrogenism.
High estrogen is typically defined as “levels exceeding the normal range” for a specific age and menstrual phase, often accompanied by other symptoms (more on this soon), she says.
Anabolic steroids may also be a major cause of high androgen and estrogen functional activity. Other possible causes include head injuries and brain inflammatory diseases. [ 3 ] Hypergonadism may contribute to symptoms such as precocious puberty and abnormal facial hair growth in females.
Estrogen also impacts norepinephrine, the neurotransmitter that regulates the fight-or-flight response, and can increase alertness. Imbalances can raise blood pressure and cause anxiety and panic.
Reality: Bioidentical estrogen, which requires a prescription just like HRT, contains estradiol, the major form of estrogen circulating in the blood of premenopausal women. “It’s a genius ...