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Radiation-induced lung injury (RILI) is a general term for damage to the lungs as a result of exposure to ionizing radiation. [1] In general terms, such damage is divided into early inflammatory damage ( radiation pneumonitis ) and later complications of chronic scarring ( radiation fibrosis ).
Radiation, used to treat cancer, can cause pneumonitis when applied to the chest or full body. [16] Radiation pneumonitis occurs in approximately 30% of advanced lung cancer patients treated with radiation therapy. [16] Aspiration pneumonitis is caused by a chemical inhalation of harmful gastric contents which include causes such as:
Side effects on the lungs can be very varied, and can include signs and symptoms that are either clinical, or radiological (i.e., seen on chest X-ray or CT), or both.They can include lung inflammation (pneumonitis), secondary (in this context, indirectly caused) lung infection (), lung fibrosis, organising pneumonia (bronchiolitis obliterans organising pneumonia, BOOP), ARDS (acute respiratory ...
The lungs are the most radiosensitive organ, and radiation pneumonitis can occur leading to pulmonary insufficiency and death (100% after exposure to 50 Gray of radiation), in a few months. Radiation pneumonitis is characterized by: [10] Loss of epithelial cells; Edema; Inflammation; Occlusions of airways, air sacs and blood vessels; Fibrosis
Radiation-induced lung injury (RILI) encompasses radiation pneumonitis and pulmonary fibrosis. Lung tissue is sensitive to ionizing radiation, tolerating only 18–20 Gy, [41] a fraction of typical therapeutic dosage levels. The lung's terminal airways and associated alveoli can become damaged, preventing effective respiratory gas exchange.
For comparison, radiation levels inside the United States Capitol are 85 mrem/yr (0.85 mSv/yr), close to the regulatory limit, because of the uranium content of the granite structure. [14] The NRC sets the annual total effective dose of full body radiation, or total body radiation (TBR), allowed for radiation workers 5,000 mrem (5 rem). [15] [16]
Acute radiation syndrome (ARS), also known as radiation sickness or radiation poisoning, is a collection of health effects that are caused by being exposed to high amounts of ionizing radiation in a short period of time. [1] Symptoms can start within an hour of exposure, and can last for several months.
Acute interstitial pneumonitis (also known as acute interstitial pneumonia) is a rare, severe lung disease that usually affects otherwise healthy individuals. There is no known cause or cure. Acute interstitial pneumonitis is often categorized as both an interstitial lung disease and a form of acute respiratory distress syndrome (ARDS).