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Doxycycline, doxycycline monohydrate and doxycycline hyclate are yellow, crystalline powders with a bitter taste. The latter smells faintly of ethanol , a 1% aqueous solution has a pH of 2–3, and the specific rotation is [ α ] D 25 {\displaystyle [\alpha ]_{D}^{25}} −110° cm 3 /dm·g in 0.01 N methanolic hydrochloric acid .
Tetracyclines are generally used in the treatment of infections of the urinary tract, respiratory tract, and the intestines and are also used in the treatment of chlamydia, especially in patients allergic to β-lactams and macrolides; however, their use for these indications is less popular than it once was due to widespread development of resistance in the causative organisms.
[13] [15] Pneumonia is also the leading cause of death in children less than five years of age in low income countries. [15] The most common cause of pneumonia is pneumococcal bacteria, Streptococcus pneumoniae accounts for 2/3 of bacteremic pneumonias. [16] Invasive pneumococcal pneumonia has a mortality rate of around 20%. [14]
There are roughly 450 million cases of pneumonia every year. Of those case, viral pneumonia counts for about 200 million cases which includes about 100 million children and 100 million adults. [14] Viral pneumonia is more prevalent in the very young, less than 5 years old, and in the very old, more than 75 years old. [14] Developing countries ...
Atypical bacteria causing pneumonia are Coxiella burnetii, Chlamydophila pneumoniae (), Mycoplasma pneumoniae (), and Legionella pneumophila.. The term "atypical" does not relate to how commonly these organisms cause pneumonia, how well it responds to common antibiotics or how typical the symptoms are; it refers instead to the fact that these organisms have atypical or absent cell wall ...
In children, most deaths (over two million a year) occur in the newborn period. According to a World Health Organization estimate, one in three newborn deaths result from pneumonia. [ 30 ] Mortality decreases with age until late adulthood, with the elderly at risk for CAP and its associated mortality.
According to the CDC, [27] "Doctors often avoid prescribing doxycycline to young children because of a warning that tooth staining may occur when used in children less than 8 years old. ..Misperceptions about the use of doxycycline for children prevent kids from getting lifesaving treatment" of rickettsial diseases.
A hyclate (Latin: hyclas) is a pharmaceutical term for hydrochloride hemiethanolate hemihydrate [1] [2] (·HCl· 1 / 2 EtOH· 1 / 2 H 2 O), e.g. doxycycline hyclate. [ 3 ] [ 4 ] References