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A conjugate vaccine is a type of subunit vaccine which combines a weak antigen with a strong antigen as a carrier so that the immune system has a stronger response to the weak antigen. Vaccines are used to prevent diseases by invoking an immune response to an antigen, part of a bacterium or virus that the immune system recognizes. [ 2 ]
Conjugate vaccines are the same in that they have a polysaccharide component, but that sugar is stuck to a protein so your immune system will respond to the sugar on the bacteria better, Dr. Scully says.
A new typhoid conjugate vaccine, consisting of Vi conjugated to tetanus toxoid (Typbar TCV), has shown promising immunogenicity and safety results in clinical trials.
Pneumococcal conjugate vaccine. Pneumococcal conjugate vaccine helps protect against bacteria that cause pneumococcal disease. There are three pneumococcal conjugate vaccines (PCV13, PCV15, and PCV20). The different vaccines are recommended for different people based on age and medical status.
Conjugate vaccines exist that offer protection against disease caused by Haemophilus influenzae type b (Hib), and selected serogroups/serotypes of Neisseria meningitidis and Streptococcus pneumoniae. These vaccines are not only able to prevent serious disease, but they also provide protection against asymptomatic carriage.
Conjugate vaccines are the most effective form of immunization for those under two years of age who are particularly vulnerable to bacterial meningitis. High-income countries have reported an increase in invasive pneumococcal disease from non-vaccine serotypes with the introduction of conjugate vaccines.
The conjugate vaccine is taken up by dendritic cells at the site of immunization and, within a few days, is transported to lymph nodes where the presence of a T cell–dependent antigen triggers the formation of GCs.
A conjugate vaccine is a therapeutic agent that stimulates the immune system to recognize and attack potential pathogens or diseased cells by using a carrier molecule to link haptens, which are small molecules derived from the pathogen or antigen, and trigger an immune response.
A conjugate vaccine is a substance that is composed of a polysaccharide antigen fused (conjugated) to a carrier molecule. This enhances the stability and the effectiveness of the...
A protein capsular matrix vaccine, where capsule is trapped in a protein matrix, produced an equivalent immune response in mice to a covalently linked conjugate vaccine, 76 and alternative ...