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Atlantoaxial instability is a common asymptomatic finding in rheumatoid arthritis patients. [3] However, it can lead to cervical myelopathy. [4] Patients with atlantoaxial instability can experience neck pain and headaches in the back of the head (occipital headaches).
Craniocervical instability is more common in people with a connective tissue disease, including Ehlers-Danlos syndromes, [1] osteogenesis imperfecta, and rheumatoid arthritis. [2] It is frequently co-morbid with atlanto-axial joint instability, Chiari malformation , [ 3 ] or tethered spinal cord syndrome .
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. [1] It typically results in warm, swollen, and painful joints. [1] Pain and stiffness often worsen following rest. [1] Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. [1]
Symptoms of optic neuritis in the affected eye include pain on eye movement, sudden loss of vision, and decrease in color vision (especially reds). Optic neuritis, when combined with the presence of multiple demyelinating white matter brain lesions on MRI, is suspicious for multiple sclerosis .
Approximately 60% of MCTD patients develop visible arthritis, frequently with rheumatoid arthritis (RA) deformities such as boutonniere deformities and swan neck alterations. [ 16 ] [ 22 ] Other features include tiny marginal erosions [ 23 ] [ 24 ] and destructive arthritis, such as arthritis mutilans .
Rheumatism [2] /ˈruməˌtɪzəm/ or rheumatic disorders are conditions causing chronic, often intermittent pain affecting the joints or connective tissue. [3] Rheumatism does not designate any specific disorder, but covers at least 200 different conditions, including arthritis and "non-articular rheumatism", also known as "regional pain syndrome" or "soft tissue rheumatism".
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