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In medicine, tapering is the practice of gradually reducing the dosage of a medication to reduce or discontinue it. Generally, tapering is done is to avoid or minimize withdrawal symptoms that arise from neurobiological adaptation to the drug.
In a comparison study, a rapid taper using benzodiazepines was found to be superior to a phenobarbital rapid taper. [106] [107] Pregabalin may help reduce the severity of benzodiazepine withdrawal symptoms, [108] and reduce the risk of relapse. [109] Propranolol was not found to increase the discontinuation success rate. [86]
Pregabalin, sold under the brand name Lyrica among others, is an anticonvulsant, analgesic, and anxiolytic amino acid medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless legs syndrome, opioid withdrawal, and generalized anxiety disorder (GAD). [13] [17] [18] Pregabalin also has antiallodynic properties.
The most commonly used strategy is to offer opioid drug users long-acting opioid drugs and slowly taper the dose of the drug. Methadone, buprenorphine-naloxone, and naltrexone are all commonly used medications for opioid use disorder. [19] A review of UK hospital policies found that local guidelines delayed access to substitute opioids.
New research suggests that slowly tapering off GLP-1 drugs like Ozempic and Wegovy while adopting lifestyle changes may help prevent rebound weight gain.
Bluelight is a web-forum, research portal, online community, and non-profit organization dedicated to harm reduction in drug use. [1] [2] Its userbase includes current and former substance users, academic researchers, drug policy activists, and mental health advocates.
However, after extensive searching it was discovered that one enantiomer of the relatively simple derivative 4-methylpregabalin, was both 4× higher in binding affinity to α 2 δ channels than pregabalin, and also retained similar affinity for the system L transporter. This was tested in animals and as hoped, was found to have similar ...
They booed former President Donald Trump, the Republican presidential candidate who currently leads in polling in some swing states. They rejected Robert F. Kennedy Jr., the independent candidate ...