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Recombinant BMP-2 and BMP-7 are currently approved for human use. [6] rhBMPs are used in oral surgeries. [7] [8] [9] BMP-7 has also recently found use in the treatment of chronic kidney disease (CKD). BMP-7 has been shown in murine animal models to reverse the loss of glomeruli due to sclerosis.
BMP7 also has the potential for treatment of chronic kidney disease. [15] [16] Kidney disease is characterized by derangement of the tubular architecture by both myofibroblast buildup and monocyte infiltration [17] Because endogenous BMP-7 is an inhibitor of the TGF-β signaling cascade that induces fibrosis, the use of exogenous recombinant ...
Congress referred to BMP in several sections of the U.S. Clean Water Act (CWA) but did not define the term. The 1977 CWA used the term in describing the areawide waste treatment planning program [ 2 ] and in procedures for controlling toxic pollutants associated with industrial discharges. [ 3 ]
There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity. Nephrotoxicity should not be confused with some medications predominantly excreted by the kidneys needing their dose adjusted for the decreased kidney function (e.g., heparin, lithium).
Samoyeds can be affected by basement membrane disease of the kidneys. It is inherited through the X chromosome and is therefore more severe in affected male dogs. Findings in male dogs include the presence of protein and glucose in the urine and the inability to concentrate urine, and progression to kidney failure by the age of 9 months and death by 16 months. [3]
Cavalier King Charles Spaniel with bandaged foot A dog's injured leg. The health of dogs is a well studied area in veterinary medicine.. Dog health is viewed holistically; it encompasses many different aspects, including disease processes, genetics, and nutritional health, for example.
Cats can tolerate transplantation from unrelated cats, but must be supported with immunosuppressive drugs for the rest of their lives. When the transplanted kidney is implanted in the recipient the original kidneys are usually left in place. [1] There are currently ten centers in the world that offer kidney transplants for cats. Most are in the US.
Preliminary research in kidney cell lines have identified nitazoxanide, closantel sodium, and closantel as drugs which have the most potential as broad-spectrum antiviral agents against canine parvovirus and its various subspecies, raising the prospect that these drugs may yield potential for future treatments of this disease. [8] [9]