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Primary (or essential) hypertension represents between 85% and 95% of human cases and has an unidentified cause. In contrast, secondary hypertension is caused by identifiable underlying conditions, including renal artery stenosis, pheochromocytoma, adrenal adenoma, or single-gene mutations.
Pathophysiology of Hypertension. The Mosaic Theory and Beyond. David G. Harrison , Thomas M. Coffman, Christopher S. Wilcox. ABSTRACT: Dr Irvine Page proposed the Mosaic Theory of Hypertension in the 1940s advocating that hypertension is the result of many factors that interact to raise blood pressure and cause end-organ damage.
Hypertension (HTN), defined as systolic blood pressure (SBP) > 140 mmHg or diastolic blood pressure (DBP) > 90 mmHg, is a major growing health problem across the globe [1-5]. It is the most common risk factor for cardiovascular disease and affects nearly two-thirds of adults aged 60 years or older [1,2].
Increased systemic vascular resistance, increased vascular stiffness, and increased vascular responsiveness to stimuli are central to the pathophysiology of hypertension. Morbidity and mortality attributable to hypertension result from target organ involvement.
Compendium on the Pathophysiology and Treatment of Hypertension. Adherence in Hypertension. A Review of Prevalence, Risk Factors, Impact, and Management. Michel Burnier, Brent M. Egan. Abstract: The global epidemic of hypertension is largely uncontrolled and hypertension remains the leading cause of noncommunicable disease deaths worldwide.
This article presents an overview of the physiology of normal blood pressure (BP) control and the pathophysiologic mechanisms that predispose individuals and populations to primary hypertension. The role of genetics, environment, and the gene-environment interaction is discussed.
PDF. Tools. Share. Abstract. Despite major advances in understanding the pathophysiology of hypertension and availability of effective and safe antihypertensive drugs, suboptimal blood pressure (BP) control is still the most important risk factor for cardiovascular mortality and is globally responsible for more than 7 million deaths annually.