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Phenoxybenzamine has a long-lasting action, binding covalently to the alpha receptors. Its only current clinical use is in preparing patients with pheochromocytoma for surgery; its irreversible antagonism and the resultant depression in the maximum of the agonist dose-response curve are desirable in a situation where surgical manipulation of ...
Acepromazine, acetopromazine, or acetylpromazine (commonly known as ACP, Ace, or by the trade names Atravet or Acezine 2, number depending on mg/ml dose) is a phenothiazine derivative antipsychotic drug. It was used in humans during the 1950s as an antipsychotic, [4] but is now almost exclusively used on animals as a sedative and antiemetic.
Phenytoin/pentobarbital (trade name Beuthanasia-D Special) is an animal drug product used for euthanasia, which contains a mixture of phenytoin and pentobarbital. [1] It is administered as an intravenous injection to give animals a quick and humane death.
An uncompetitive antagonist is slightly different from the other two types of antagonists. The action of an uncompetitive antagonist is dependent on the receptor's prior activation. This means only after the agonist binds to the receptor can the antagonist block the receptor's function. [12]
It has been given in combination with a benzodiazepine to cats prior to stressful events (such as a veterinary visit) to possibly relieve hypersensitivity. [ 16 ] When compared to other antiemetics , maropitant has similar or greater effectiveness to chlorpromazine and metoclopramide for centrally mediated vomiting induced by apomorphine or ...
The LD 50 of atipamezole for rats is 44 mg/kg when given subcutaneously. The minimum lethal dose in dogs is over 5 mg/m 2 ; dogs have tolerated getting ten times the standard dose. [ 9 ] [ 33 ] Signs of overdose include panting, trembling, vomiting, and diarrhea, as well as increased blood levels of creatine kinase , aspartate transaminase ...