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Gain-of-function research (GoF research or GoFR) is medical research that genetically alters an organism in a way that may enhance the biological functions of gene products. This may include an altered pathogenesis , transmissibility , or host range , i.e., the types of hosts that a microorganism can infect.
Gain of function may refer to: Gain-of-function mutation; Gain-of-function research This page was last edited on 5 ...
Gain of function mutation was first discovered in patients with chronic mucocutaneous candidiasis (CMC). This disease is characteristic with its symptoms as persistent infections of the skin, mucosae - oral or genital and nails infections caused by Candida, mostly Candida albicans. CMC may very often result from primary immunodeficiency.
Former DNI John Ratcliffe told Congress that Fauci’s testimony under oath on gain-of-function research did not comport with the intelligence available at the time.
A neomorphic mutation causes a dominant gain of gene function that is different from the normal function. [1] A neomorphic mutation can cause ectopic mRNA or protein expression, or new protein functions from altered protein structure. Changing wildtype gene dose has no effect on the phenotype of a neomorph. [2] m/Df = m/+ = m/Dp
Pages for logged out editors learn more. Contributions; Talk; Gain-of-function
Gain-of-function, a property of a genetic mutation; Gamo-Gofa-Dawro language, spoken in Ethiopia; Gang of Four (disambiguation) Goodness of fit
STAT3 gain-of function (GOF) is a rare genetic disorder of the immune system, leading to early-onset autoimmunity and a variety of multi-organ disorders.The condition is progressive and manifests through a broad spectrum of clinical symptoms, including lymphadenopathy, autoimmune cytopenias, growth delays, enteropathy, lung disease, endocrine disorders, arthritis, autoimmune hepatitis ...