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Potassium channel blockers exhibit reverse use-dependent prolongation of the action potential duration. Reverse use dependence is the effect where the efficacy of the drug is reduced after repeated use of the tissue. [ 11 ]
Initially, open channel blockers do not effectively prevent action potentials, as few channels are blocked and the blocker itself can be released from the channel either quickly or slowly depending on its characteristics. However, phasic blocks occur as repeated depolarization increases blockers’ affinity for channels in the neuron.
Vonoprazan, sold under the brand name Voquezna among others, is a first-in-class potassium-competitive acid blocker medication. [2] [1] Vonoprazan is used in form of the fumarate for the treatment of gastroduodenal ulcer (including some drug-induced peptic ulcers) and reflux esophagitis, and can be combined with antibiotics for the eradication of Helicobacter pylori.
Sotalol also acts on potassium channels and causes a delay in relaxation of the ventricles. [16] By blocking these potassium channels, sotalol inhibits efflux of K + ions, which results in an increase in the time before another electrical signal can be generated in ventricular myocytes. [14]
HERG blocker (57 P) Pages in category "Potassium channel blockers" The following 66 pages are in this category, out of 66 total.
The latter is for medicines that block the B1 receptors found in the heart, which when activated, focus on elevated heart rate, increasing pumping force and releasing a kidney enzyme called renin.
In the laboratory, 4-AP is a useful pharmacological tool in studying various potassium conductances in physiology and biophysics. [citation needed] [14] [15] It is a relatively selective blocker of members of Kv1 (Shaker, KCNA) family of voltage-activated K+ channels.
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