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The life cycle of HIV can be as short as about 1.5 days from viral entry into a cell, through replication, assembly, and release of additional viruses, to infection of other cells. [18] HIV lacks proofreading enzymes to correct errors made when it converts its RNA into DNA via reverse transcription .
HIV is now known to spread between CD4 + T cells by two parallel routes: cell-free spread and cell-to-cell spread, i.e. it employs hybrid spreading mechanisms. [95] In the cell-free spread, virus particles bud from an infected T cell, enter the blood/extracellular fluid and then infect another T cell following a chance encounter. [95]
HIV can infect a variety of immune cells such as CD4 + T cells, macrophages, and microglial cells. HIV-1 entry to macrophages and CD4 + T cells is mediated through interaction of the virion envelope glycoproteins (gp120) with the CD4 molecule on the target cells' membrane and also with chemokine co-receptors. [26] [44]
HIV-1 is the more commonly associated with AIDS in the US and worldwide, HIV-2 is more rare, and typically restricted to areas in western Africa and southern Asia. HIV-2 is so uncommon that “HIV” almost always refers to HIV-1. Alright HIV targets CD4+ cells, meaning cells that have this specific molecule called CD4 on their membrane.
Sewage contaminated water contains many viruses, over one hundred species are reported and can lead to diseases that affect human beings. For example, hepatitis, gastroenteritis, meningitis, fever, rash, and conjunctivitis can all be spread through contaminated water. More viruses are being discovered in water because of new detection and ...
The reason for the preferential loss of mucosal CD4 + T cells is that a majority of mucosal CD4 + T cells express the CCR5 coreceptor, whereas a small fraction of CD4 + T cells in the bloodstream do so. [5] HIV seeks out and destroys CCR5 expressing CD4 + cells during acute infection. A vigorous immune response eventually controls the infection ...
Relevant microbes may be viruses, bacteria, or fungi, and they may be spread through breathing, talking, coughing, sneezing, spraying of liquids, toilet flushing or any activities which generate aerosol particles or droplets or generate fomites, such as raising of dust. [13] [14]
An infectious disease agent can be transmitted in two ways: as horizontal disease agent transmission from one individual to another in the same generation (peers in the same age group) [3] by either direct contact (licking, touching, biting), or indirect contact through air – cough or sneeze (vectors or fomites that allow the transmission of the agent causing the disease without physical ...