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After the health care provider draws the cord blood from the placental end of the umbilical cord, the placenta is couriered to the stem cell laboratory, where it is processed for additional stem cells. An adequate cord blood collection requires at least 75mL in order to ensure that there will be enough cells to be used for a transplantation.
Cord blood is being used to get stem cells with which to test in people with type 1 diabetes mellitus. [42] The stem cells from umbilical cord blood are also being used in the treatment of a number of blood diseases including blood cancers. [43] Cord blood is also being studied as a substitute for normal blood transfusions in the developing world.
In 2021, stem cell injections in the US have caused grave infections in at least 20 patients who received umbilical cord blood-derived products marketed as "stem cell treatment". [79] In 2023, the case of a woman who was infected with Mycobacterium abscessus and sustained meningitis after stem cell treatment for multiple sclerosis at a ...
The cord blood bank Cryo-Save AG shut their doors at the end of June 2019. By 17 September, they filed for liquidation. The brand name CryoSave and the client database now belong to CSG-BIO. The clients’ umbilical cords were moved in the 2nd quarter of 2019, to the Polish cord blood bank PBKM, the head of the FamiCord network.
The umbilical cord lining membrane is a rich source of two strains of stem cells (CLSCs): epithelial stem cells (from the amniotic layer) (CLECs) and mesenchymal stem cells (from the sub-amniotic layer) (CLMCs). Discovered by Singapore-based CellResearch Corporation in 2004, this is the best known source for harvesting human stem cells.
Allogeneic transplants are also performed using umbilical cord blood as the source of stem cells. In general, by transfusing healthy stem cells to the recipient's bloodstream to reform a healthy immune system, allogeneic HSCTs appear to improve chances for cure or long-term remission once the immediate transplant-related complications are resolved.