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Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, migraines, or surgery. [8] It is also effective for treating gastroenteritis. [9] [10] It can be given orally (by mouth), intramuscularly (injection into a muscle), or intravenously ...
Dose; Ondansetron: Carbazole derivative 5-HT 3 receptor antagonist and weak 5-HT 4 antagonist 3.9 hours CYP1A1/2, CYP2D6, CYP 3A3/4/5: 150 μg/kg Granisetron: Indazole: 5-HT 3 receptor antagonist 9–11.6 hours CYP3A3/4/5: 10 μg/kg Dolasetron: Indole: 5-HT 3 receptor antagonist 7–9 hours CYP 3A3/4/5, CYP2D6: 600 – 3000 μg/kg Palonosetron ...
Ondansetron (Zofran) is administered in an oral tablet form, orally dissolving tablet form, orally dissolving film, sublingual, or in an IV/IM injection. Tropisetron ( Setrovel, Navoban ) can be administered in oral capsules or in injection form.
Tricyclics have a narrow therapeutic index, i.e., the therapeutic dose is close to the toxic dose. [7] Factors that increase the risk of toxicity include advancing age, cardiac status, and concomitant use of other drugs. [8] However, serum drug levels are not useful for evaluating risk of arrhythmia or seizure in tricyclic overdose. [9]
Having vomited for a long period prior to attending a hospital, patients are typically severely dehydrated. For a number of patients, potent anti-emetic drugs such as ondansetron (Zofran) or granisetron (Kytril), and dronabinol (Marinol) may be helpful in either preventing an attack, aborting an attack, or reducing the severity of an attack ...
A few facts for you according to the folks from The Anxiety and Depression Association of America and the National Institute of Mental Health: In 2020, an estimated 14.8 million U.S. adults aged ...