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Chlortalidone is considered a first-line medication for treatment of high blood pressure. [2] Some recommend chlortalidone over hydrochlorothiazide. [1] [15] A meta-analysis of randomized controlled trials found that chlortalidone is more effective than hydrochlorothiazide for lowering blood pressure, while the two drugs have similar toxicity.
“There are many medications that may cause weight gain,” says W. Scott Butsch, M.D., director of obesity medicine in the Bariatric and Metabolic Institute at the Cleveland Clinic.
Thiazolidinediones may cause slight weight gain but decrease "pathologic" abdominal fat (visceral fat), and therefore may be prescribed for diabetics with central obesity. [115] Thiazolidinedione has been associated with heart failure and increased cardiovascular risk; so it has been withdrawn from the market in Europe by EMA in 2010. [116]
Smoking has a significant effect on an individual's weight. Those who quit smoking gain an average of 4.4 kilograms (9.7 lb) for men and 5.0 kilograms (11.0 lb) for women over ten years. [156] However, changing rates of smoking have had little effect on the overall rates of obesity. [157]
Sasha Pieterse discussed the challenges of gaining 70 pounds at age 17 — while filming a hit TV series — due to her experience with polycystic ovary syndrome. “This is part of the health ...
Researchers analyzed the weights of more than 183,000 adult antidepressant users six months, a year and two years after they started taking the drugs.
Setmelanotide is an agonist of the melanocortin 4 receptor and is used in people with certain rare genetic conditions that cause obesity. It is less effective and not approved for general obesity. [16] Some weight loss drugs act on the neurotransmitters serotonin, dopamine, and norepinephrine to reduce appetite. [17]
Over the years, several studies and meta-analyses have found that people who use bupropion to treat depression tend to gain less weight than their peers, with some people prescribed this ...