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Levofloxacin had reached blockbuster status by this time; combined worldwide sales of levofloxacin and ofloxacin for J&J alone were US$1.6 billion in 2009. [ 67 ] The term of the levofloxacin United States patent was extended by the U.S. Patent and Trademark Office 810 days under the provisions of the Hatch Waxman Amendment so that the patent ...
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Fluoroquinolones have varying specificity for cytochrome P450, so may have interactions with drugs cleared by those enzymes; the order from most P450-inhibitory to least, is enoxacin > ciprofloxacin > norfloxacin > ofloxacin, levofloxacin, trovafloxacin, gatifloxacin, moxifloxacin. [50]
The following is a list of antibiotics.The highest division between antibiotics is bactericidal and bacteriostatic.Bactericidals kill bacteria directly, whereas bacteriostatics prevent them from dividing.
Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin. [52] "After multiple-dose administration of 200 mg and 300 mg doses, peak serum levels of 2.2 and 3.6 μg/ml, respectively, are predicted at steady-state.
IC 50 values are typically expressed as molar concentration. IC 50 is commonly used as a measure of antagonist drug potency in pharmacological research. IC 50 is comparable to other measures of potency, such as EC 50 for excitatory drugs. EC 50 represents the dose or plasma concentration required for obtaining 50% of a maximum effect in vivo. [1]
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