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A foreign-body giant cell is a collection of fused macrophages which are generated in response to the presence of a large foreign body. This is particularly evident with catheters, parasites, or biomaterials that are inserted into the body for replacement or regeneration of diseased or damaged tissues.
A foreign body reaction (FBR) is a typical tissue response to a foreign body within biological tissue. [1] It usually includes the formation of a foreign body granuloma . [ 2 ] Tissue encapsulation of an implant is an example, as is inflammation around a splinter . [ 3 ]
Applications of bioinstructive materials as substrates for stem cell production, [6] cell delivery and reduction of foreign body reaction [7] [8] and coatings to reduce infections on medical devices. [ 9 ] [ 10 ] This non-leaching approach is distinct from strategies of infection control relying on antibiotic release, [ 11 ] cytokine delivery ...
Non-osteoclast MGCs can arise in response to an infection, such as tuberculosis, herpes, or HIV, or as part of a foreign body reaction. These MGCs are cells of monocyte or macrophage lineage fused together. Similar to their monocyte precursors, they can phagocytose foreign materials. However, their large size and extensive membrane ruffling ...
Two major types of reaction occur in response to retained surgical foreign bodies. In the first type, an abscess may form with or without a secondary bacterial infection. The second reaction is an aseptic fibrinous response, resulting in tissue adhesions and encapsulation and eventually foreign body granuloma. [2]
[9] [24] In order for a biodegradable polymer to be used as a therapeutic, it must meet several criteria: 1) be non-toxic in order to eliminate foreign body response; 2) the time it takes for the polymer to degrade is proportional to the time required for therapy; 3) the products resulting from biodegredation are not cytotoxic and are readily ...
The ideal cell response to a bioactive surface is characterized by biomaterial stabilization and integration, as well as the reduction of potential bacterial infection sites on the surface. One example of biomaterial integration is a titanium implant with an engineered biointerface covered with biomimetic motifs. Surfaces with these biomimetic ...
Inflammation, a common occurrence after any surgical procedure, is the body's response to tissue damage as a result of trauma, infection, intrusion of foreign materials, or local cell death, or as a part of an immune response. Inflammation starts with the rapid dilation of local capillaries to supply the local tissue with blood. The inflow of ...