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Depression is a mental state of low mood and aversion to activity. [3] It affects about 3.5% of the global population, or about 280 million people worldwide, as of ...
Engraving by Jusepe de Ribera depicting the melancholic and world-weary figure of a poet. Weltschmerz (German: [ˈvɛltʃmɛɐ̯ts] ⓘ; literally "world-pain") is a literary concept describing the feeling experienced by an individual who believes that reality can never satisfy the expectations of the mind, [1] [2] resulting in "a mood of weariness or sadness about life arising from the acute ...
Although melancholia remained the dominant diagnostic term, depression gained increasing currency in medical treatises and was a synonym by the end of the century; German psychiatrist Emil Kraepelin may have been the first to use it as the overarching term, referring to different kinds of melancholia as depressive states. [15]
Depression (kinesiology), an anatomical term of motion, refers to downward movement, the opposite of elevation; Depression (physiology), a reduction in a biological variable or the function of an organ; Central nervous system depression, physiological depression of the central nervous system that can result in loss of consciousness
This article needs to be updated. The reason given is: Many outdated sources and information (older than five years). Please help update this article to reflect recent events or newly available information. (July 2024) Medical condition Major depressive disorder Other names Clinical depression, major depression, unipolar depression, unipolar disorder, recurrent depression Sorrowing Old Man (At ...
Physiognomy of the melancholic temperament (drawing by Thomas Holloway, c.1789, made for Johann Kaspar Lavater's Essays on Physiognomy). Melancholia or melancholy (from Greek: µέλαινα χολή melaina chole, [1] meaning black bile) [2] is a concept found throughout ancient, medieval, and premodern medicine in Europe that describes a condition characterized by markedly depressed mood ...
Antagonizing the κ-opioid receptor may be able to treat depression, anxiety, stress, addiction, and alcoholism. [143] The third receptor is the δ-opioid receptor (DOR). The delta receptor is the least studied of the three main opioid receptors. It is a G protein-coupled receptor, and its endogenous ligand is deltorphin.
Anhedonia is a diverse array of deficits in hedonic function, including reduced motivation or ability to experience pleasure. [1] While earlier definitions emphasized the inability to experience pleasure, anhedonia is currently used by researchers to refer to reduced motivation, reduced anticipatory pleasure (wanting), reduced consummatory pleasure (liking), and deficits in reinforcement learning.