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Lamotrigine is expressed in breast milk; the manufacturer recommends carefully weighing the benefits and risks of taking lamotrigine while breastfeeding. [62] However, some studies suggest that lamotrigine is safe to use while breastfeeding. [63] A frequently updated review of scientific literature rates lamotrigine as L3: moderately safe. [64]
Use during breastfeeding appears to be relatively safe. [7] It is a tricyclic antidepressant (TCA) and is believed to work by altering levels of serotonin and norepinephrine. [8] Nortriptyline was approved for medical use in the United States in 1964. [8] It is available as a generic medication. [7]
[5] [8] It is unclear if use during pregnancy or breastfeeding is safe. [9] Desvenlafaxine was approved for medical use in the United States in 2008. [5] In Europe its application for use was denied in 2009. [6] In 2022, it was the 208th most commonly prescribed medication in the United States, with more than 1 million prescriptions. [10] [11]
The first-ever pill for postpartum depression, zuranolone, was approved last year. ... to be an exciting time. The new mother had just given birth at age 42, after a much-desired pregnancy ...
Recent reports indicate that a reciprocal or bidirectional relationship exists between breastfeeding and postpartum depression. [5] That is, postpartum depression results in reduced breastfeeding activity and early cessation, and abstinence from breastfeeding or irregularity in practicing it increases risk of developing postpartum depression. [5]
Postpartum depression (PPD), also called perinatal depression, is a mood disorder which may be experienced by pregnant or postpartum individuals. [3] Symptoms include extreme sadness, low energy, anxiety, crying episodes, irritability, and changes in sleeping or eating patterns. [1] PPD can also negatively affect the newborn child. [4] [2]
Tricyclic antidepressants are older antidepressants that, due to their side effect profiles, typically aren’t prescribed as first-line depression treatments today.
Research regarding the effectiveness of antidepressants for depression in adults is controversial and has found both benefits [14] and drawbacks. [15] Meanwhile, evidence of benefit in children and adolescents is unclear, [ 16 ] [ 17 ] even though antidepressant use has considerably increased in children and adolescents in the 2000s. [ 18 ]