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M72/AS01 E is an experimental tuberculosis vaccine. If approved, it would be the first vaccine for tuberculosis in more than a century after the BCG vaccine. [1] [2] The vaccine consists of two main ingredients. The antigen part is M72, a recombinant fusion protein derived from the sequences of two M. tuberculosis antigens (Mtb32A and Mtb39A ).
Racquel Chevremont (born June 25, 1971) is an American curator, art collector, advisor, model, and television personality.Chevremont is best known for her contemporary art curation, which has been shown in both gallery and institutional exhibitions as well as in popular media and culture, and for starring in the fifteenth season of The Real Housewives of New York City.
Tuberculosis (TB) vaccines are vaccinations intended for the prevention of tuberculosis. Immunotherapy as a defence against TB was first proposed in 1890 by Robert Koch . [ 1 ] As of 2021, the only effective tuberculosis vaccine in common use is the Bacillus Calmette-Guérin (BCG) vaccine, first used on humans in 1921.
The Bacillus Calmette–Guérin (BCG) vaccine is a vaccine primarily used against tuberculosis (TB). [9] It is named after its inventors Albert Calmette and Camille Guérin. [10] [11] In countries where tuberculosis or leprosy is common, one dose is recommended in healthy babies as soon after birth as possible. [9]
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Rigorous preclinical studies in different TB-relevant animal models - mice, guinea pigs and non-human primates - conducted between 2001 and 2011 have shown adequate attenuation, safety and improved immunogenicity and protective efficacy against M. tuberculosis challenge as compared to BCG, thus fulfilling regulatory WHO guidelines and the Geneva consensus requirements for progressing live ...
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Since its inception in 2000, TB Alliance has worked to grow the field of available treatments for TB and now manages the largest pipeline of new TB drugs in history. [1] It was founded in Cape Town, South Africa, and has since expanded. It is headquartered in New York City and has a regional office in Pretoria. [2]
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