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Potassium channel blockers exhibit reverse use-dependent prolongation of the action potential duration. Reverse use dependence is the effect where the efficacy of the drug is reduced after repeated use of the tissue. [11] This contrasts with (ordinary) use dependence, where the efficacy of the drug is increased after repeated use of the tissue.
Vonoprazan, sold under the brand name Voquezna among others, is a first-in-class potassium-competitive acid blocker medication. [2] [1] Vonoprazan is used in form of the fumarate for the treatment of gastroduodenal ulcer (including some drug-induced peptic ulcers) and reflux esophagitis, and can be combined with antibiotics for the eradication of Helicobacter pylori.
Zastaprazan (trade name Jaqbo) is a pharmaceutical drug for gastrointestinal disorders.It is classified as a potassium-competitive acid blocker. [1] [2] In April 2024, it was approved for use in South Korea for the treatment of erosive gastroesophageal reflux disease (GERD). [3]
Medications that are classified as potassium-sparing diuretics which block the epithelial sodium channel (ENaC), such as amiloride and triamterene, are seldom prescribed as monotherapy. ENaC blocker medications need stronger public evidence for their blood pressure reducing effect. [10]
Molecules that act as channel blockers are important in the field of pharmacology, as a large portion of drug design is the use of ion channel antagonists in regulating physiological response. The specificity of channel block molecules on certain channels makes it a valuable tool in the treatment of numerous disorders. [2] [3]
Proton pump inhibitors (PPIs) block the gastric hydrogen potassium ATPase (H + /K + ATPase) and inhibit gastric acid secretion. These drugs have emerged as the treatment of choice for acid-related diseases, including gastroesophageal reflux disease (GERD) and peptic ulcer disease. PPIs also can bind to other types of proton pumps such as those ...
A channel modulator, or ion channel modulator, is a type of drug which modulates ion channels. ... see also Potassium channel blocker, Potassium channel opener;
Fexuprazan (trade name Fexuclue) is a drug for the treatment of gastroesophageal reflux disease (GERD). [1] It is a potassium-competitive acid blocker. [2] Fexuprazan is approved for use in South Korea and Mexico. [3] [4]