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Signs of ITP include the spontaneous formation of bruises and petechiae (tiny bruises), especially on the extremities. Additionally, bleeding from the nostrils and/or gums, as well as menorrhagia (excessive menstrual bleeding), may occur if the platelet count falls below 20,000 per μL. [4]
Most bruises occur close enough to the epidermis such that the bleeding causes a visible discoloration. The bruise then remains visible until the blood is either absorbed by tissues or cleared by immune system action. Bruises which do not blanch under pressure can involve capillaries at the level of skin, subcutaneous tissue, muscle, or bone ...
Bruising, particularly purpura in the forearms and petechiae in the feet, legs, and mucous membranes, may be caused by spontaneous bleeding under the skin. [8] [9] Eliciting a full medical history is vital to ensure the low platelet count is not secondary to another disorder.
As a result, bruising, and rarely bleeding can occur. The bruising often takes the form of purpura, while the most common site of bleeding, if it occurs, is from the nose or gums. Larger bruises may also develop. [11] The classic presentation of TTP, which occurs in less than 10% of people, includes five medical signs. These are: [3] Fever
Initially a vascular lesion is usually noted on the skin which can be firm and hard (indurated). Areas of tiny red dots (petechiae) can appear around the lesion or on other parts of the body. If the vascular lesion is internal, these petechiae and bruising can be seen on the skin. Bruising and spontaneous bleeding can also occur.
Here's what bacterial meningitis is, how it's different from viral and other types of meningitis, and what treatment can be expected.
It was first described in 1920 by German doctors, Fritz Rabe and Eugene Salomon, studying a bleeding disorder presenting itself in a child from birth. [13] This disorder may also be simply called afibrinogenemia or familial afibrinogenemia. [4] About 1 in 1 million individuals are diagnosed with the disease; typically at birth. [14]
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