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The natural, active form of vitamin D is calcitriol (1,25-dihydroxycholecalciferol). This molecule and other naturally occurring forms of vitamin D, including its precursors and metabolites, have been modified to synthesize pharmaceuticals with potentially greater, or selective, therapeutic actions. [1] [2] [3] [4]
Paricalcitol (chemically it is 19-nor-1,25-(OH) 2-vitamin D 2. Marketed by Abbott Laboratories under the trade name Zemplar ) is a drug used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone ) associated with chronic kidney failure .
Alfacalcidol (or 1-hydroxycholecalciferol) is an analogue of vitamin D used for supplementation in humans and as a poultry feed additive. Alfacalcidol has a weaker impact on calcium metabolism [ 3 ] and parathyroid hormone levels [ 4 ] than calcitriol ; but significant effects on the immune system , including regulatory T cells . [ 5 ]
Vitamin D, a.k.a. calciferol, is a fat-soluble vitamin that’s naturally present in some foods and added to others, the NIH says. Your body also makes vitamin D when UV rays from the sun hit your ...
While there are two main forms of vitamin D, D2 (ergocalciferol) and D3 (cholecalciferol), you should integrate vitamin D3. Related: 11 Best Vitamin D Supplements of 2021
Calcitriol was identified as the active form of vitamin D in 1971 and the drug was approved for medical use in the United States in 1978. [7] It is available as a generic medication. [12] In 2022, it was the 254th most commonly prescribed medication in the United States, with more than 1 million prescriptions.
People diagnosed with schizophrenia tend to have lower serum vitamin D concentrations compared to those without the condition. This may be a consequence of the disease rather than a cause, due, for example, to low dietary vitamin D and less time spent exposed to sunlight. [151] [152] Results from supplementation trials have been inconclusive. [151]
Vitamin D is an important nutrient that's top of mind for many lately, and that's good news since most people in the United States don't consume enough of it, according to the National Institutes ...