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Paradoxical laughter has been consistently identified as a recurring emotional-cognitive symptom in schizophrenia diagnosis. Closely linked to paradoxical laughter is the symptom; inappropriate affect, defined by the APA Dictionary of Psychology as "emotional responses that are not in keeping with the situation or are incompatible with expressed thoughts or wishes". [3]
Nuedexta – dextromethorphan hydrobromide 20 mg/quinidine sulfate 10 mg (N=107) 283 patients (86.8%) completed the study. The number of PBA episodes (laughing, crying or aggressive outbursts) were 47% and 49% lower (based on the trial's outcome measures), respectively, for the drug-combination options than for the placebo.
Inappropriate affect is an emotional expression that does not align with the content of a person's speech or thoughts, or is unsuitable for the situation at hand. [1] This is often observed in individuals with schizophrenia, [2] where emotional responses, such as laughter, may occur in the absence of a relevant stimulus.
The DSM-5 criteria puts more emphasis on social or occupational dysfunction than the ICD-10. [7] The ICD-10, on the other hand, puts more emphasis on first-rank symptoms. [2] [8] The current proposal for the ICD-11 criteria for schizophrenia recommends adding self-disorder as a symptom. [9]
Schizophreniform disorder is a type of mental illness that is characterized by psychosis and closely related to schizophrenia.Both schizophrenia and schizophreniform disorder, as defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR), have the same symptoms and essential features except for two differences: the level of functional impairment and the duration of symptoms.
The early idea that a person with schizophrenia might present solely with symptoms and indications of deterioration (i.e. presenting with no accessory symptoms [18] [19]) was identified as dementia simplex. [20] ICD-10 specifies the continuation of symptoms for a period of two years in the diagnosis of simple schizophrenia.
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