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Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19 [5]) is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatin [5] of the cell nucleus.
The cause of PML is a type of polyomavirus called the JC virus (JCV), after the initials of the person (John Cunningham) from whose tissue the virus was first successfully cultured. Publications indicate 39 [ 3 ] to 58% [ 4 ] of the general population are seropositive for antibodies to JCV, indicating current or previous infection with the virus.
Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARA) gene on chromosome 17. [3] In 95% of cases of APL, the RARA gene on chromosome 17 is involved in a reciprocal translocation with the promyelocytic leukemia gene (PML) on chromosome 15, a translocation denoted as t(15;17)(q22;q21). [3]
Heroin, for example, is generally undetectable in urine after three to five days. As the chart below shows, traces of drugs like LSD, morphine, heroin, amphetamines, and alcohol all remain in the ...
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A new study found that omega-3 slowed biological aging by up to four months, with vitamin D and strength training boosting the effects: A neurologist explains.
PRES usually has an acute onset. Most people with PRES experience headaches and seizures; many also experience visual changes, confusion, drowsiness, weakness of the arm and/or leg on one side of the body (hemiplegia), difficulty speaking, or, more rarely, other neurological symptoms. Some people with PRES may experience coma. [2]