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The opening includes no less than four distinct citrus notes: bergamot, bitter orange, lemon, and mandarin orange. ... products that specifically address the negative side effects of sweating ...
The bergamot is a citrus fruit native to southern Italy. Production is mostly limited to the Ionian Sea coastal areas of the province of Reggio di Calabria in Italy, to such an extent that it is a symbol of the entire city. Most of the bergamot comes from a short stretch of land there, where the temperature is favourable.
Bergamottin and dihydroxybergamottin are linear furanocoumarins functionalized with side chains derived from geraniol. They are inhibitors of some isoforms of the cytochrome P450 enzyme, in particular CYP3A4. [2] This prevents oxidative metabolism of certain drugs by the enzyme, resulting in an elevated concentration of drug in the bloodstream.
Anti-inflammatory and antioxidant effects – Emerging research indicates citropten might have anti-inflammatory and antioxidant capabilities. [8] These properties could hold promise for various health applications. The pleasant aroma of citropten makes it a valuable component in the fragrance industry, used in perfumes and cosmetics. [9]
Researchers have identified over 85 drugs with which grapefruit reacts adversely. [ 45 ] [ 1 ] According to a review done by the Canadian Medical Association , [ 1 ] there is an increase in the number of potential drugs that can interact with grapefruit juice, and of the number of fruit types that can interact with those drugs.
A review of 12 studies revealed a higher prevalence of ED among men with anxiety disorders. But more research is needed to confirm these mental health conditions as an independent factor for ED.
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