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Vitamin K epoxide reductase (VKOR) is an enzyme (EC 1.17.4.4) that reduces vitamin K after it has been oxidised in the carboxylation of glutamic acid residues in blood coagulation enzymes. VKOR is a member of a large family of predicted enzymes that are present in vertebrates, Drosophila , plants, bacteria and archaea . [ 1 ]
In enzymology, a vitamin-K-epoxide reductase (warfarin-insensitive) (EC 1.17.4.5) is an enzyme that catalyzes the chemical reaction 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol ⇌ {\displaystyle \rightleftharpoons } 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
In enzymology, a vitamin-K-epoxide reductase (warfarin-sensitive) (EC 1.17.4.4) is an enzyme that catalyzes the chemical reaction 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol ⇌ {\displaystyle \rightleftharpoons } 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
Vitamin K is a fat-soluble vitamin, so you’ll best absorb it in a fat-containing meal. Don’t overlook the 10 vitamins that should always be taken with food. Women ages 19 and older need 90 ...
The availability of reduced vitamin K is of importance for activation vitamin K 2,3-epoxide. The reduction of vitamin K epoxide is then responsible for the carboxylation of glutamic acid residues in some blood-clotting proteins, including factor VII, factor IX, and factor X. [5] [7] VKORC1 is of therapeutic interest both for its role in ...
[2] [3] [6] Vitamin K can be delivered into the body via the oral, subcutaneous, intramuscular, or intravenous routes of administration. [7] Vitamin K can influence bone health, coagulation, and insulin sensitivity, but it can also be effected by bariatric surgery which can result in vitamin K deficiency.