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Fibrous dysplasia is a very rare [2] nonhereditary genetic disorder where normal bone and marrow is replaced with fibrous tissue, resulting in formation of bone that is weak and prone to expansion. As a result, most complications result from fracture , deformity, functional impairment, pain, and the impingement of nerves. [ 3 ]
Fibrodysplasia ossificans progressiva (/ ˌ f aɪ b r oʊ d ɪ ˈ s p l eɪ ʒ (i) ə ɒ ˈ s ɪ f ɪ k æ n z p r ə ˈ ɡ r ɛ s ɪ v ə /; [1] abbr. FOP), also called Münchmeyer disease or formerly myositis ossificans progressiva, is an extremely rare connective tissue disease in which fibrous connective tissue such as muscle, tendons, and ligaments turn into bone tissue (ossification).
Fibrous dysplasia causes bone thinning [13] and growths or lesions in one or more bones of the human body. These lesions are tumor-like growths that consist of replacement of the medullary bone with fibrous tissue, causing the expansion and weakening of the areas of bone involved. Especially when involving the skull or facial bones, the lesions ...
Fibrous dysplasia and its treatment Fibrous dysplasia is a rare congenital disease of the bone that often affects the cranial facial structures, Dr. Netanel Ben-Shalom, a nuerosurgeon, at ...
Denosumab has been found successful in reducing bone pain and decreasing tumor growth, however there is limited safety data available in patients with fibrous dysplasia. [21] Muscle strengthening exercises are important for preventing bone fractures; cycling and swimming are recommended in order to reduce the risk of fracture during exercise. [17]
It comprises a majority of the cases of fibrous dysplasia (approximately 70–80%). [2] It is a rare bone disease characterized by the replacement of normal elements of the bone by fibrous connective tissue, [3] which can cause very painful swellings and bone deformities, and make bone abnormally fragile and prone to fracture. [4]
Around 550 cases of primary bone cancer – a cancer that begins in the bones – are diagnosed in the UK each year
Polyostotic fibrous dysplasia is a form of fibrous dysplasia affecting more than one bone. [2] Fibrous dysplasia is a disorder where bone is replaced by fibrous tissue, leading to weak bones, uneven growth, and deformity. [3] McCune–Albright syndrome includes polyostotic fibrous dysplasia as part of its presentation. [4]