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It was discovered in 2000 as one of two improved mutants by H. Bujard and his colleagues after random mutagenesis of the Tet repressor part of the transactivator gene. [6] Tet-On 3G (also known as rtTA-V10 [7]) is similar to Tet-On Advanced but was derived from rtTA2 S-S2 rather than rtTA2 S-M2. It is also human codon optimized and composed of ...
The transactivator gene expresses a transcription factor that binds to specific promoter region of DNA. By binding to the promoter region of a gene, the transcription factor causes that gene to be expressed. The expression of one transactivator gene can activate multiple genes, as long as they have the same, specific promoter region attached.
A user will input a number and the Calculator will use an algorithm to search for and calculate closed-form expressions or suitable functions that have roots near this number. Hence, the calculator is of great importance for those working in numerical areas of experimental mathematics. The ISC contains 54 million mathematical constants.
Thus TET enzymes largely initiate demethylation at 5mCpG sites. Oxoguanine glycosylase (OGG1) is one example of a protein that recruits a TET enzyme. TET1 is able to act on 5mCpG if an ROS has first acted on the guanine to form 8-hydroxy-2'-deoxyguanosine (8-OHdG or its tautomer 8-oxo-dG), resulting in a 5mCp-8-OHdG dinucleotide (see Figure). [10]
The book is aimed at a "general mathematical audience" [1] including undergraduate mathematics students with an introductory-level background in real analysis. [2] It is intended both to excite mathematicians, physicists, and computer scientists about the foundational issues in their fields, [6] and to provide an accessible introduction to the subject.
[2] [3] Binding of the activator-coactivator complex increases the speed of transcription by recruiting general transcription machinery to the promoter, therefore increasing gene expression. [ 3 ] [ 4 ] [ 5 ] The use of activators and coactivators allows for highly specific expression of certain genes depending on cell type and developmental stage.
The comparison with experiment is quantified using a function of the form χ 2 = Σ (y obs − y calc) 2 / σ 2. where y obs and y calc are the observed (measured) and calculated quantities respectively, and σ is a measure of the accuracy of the measurement. The sum is over all independent measurements, which will include the sum over all ...
Let S be a statement of the form P implies Q (P → Q). Then the converse of S is the statement Q implies P (Q → P). In general, the truth of S says nothing about the truth of its converse, [2] unless the antecedent P and the consequent Q are logically equivalent. For example, consider the true statement "If I am a human, then I am mortal."