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This article needs to be updated. The reason given is: Many outdated sources and information (older than five years). Please help update this article to reflect recent events or newly available information. (July 2024) Medical condition Major depressive disorder Other names Clinical depression, major depression, unipolar depression, unipolar disorder, recurrent depression Specialty Psychiatry ...
In modern times, depression, more often severe cases, is more noted as an absence of pleasure, with feelings of emptiness and flatness. [4] In the United States and Canada, the costs associated with major depression are comparable to those related to heart disease, diabetes, and back problems and are greater than the costs of hypertension. [5]
Depression is a mental state of low mood and aversion to activity. [3] It affects about 3.5% of the global population, or about 280 million people worldwide, as of ...
There is no laboratory test for major depression. [2] Testing however, may be done to rule out physical conditions that can cause similar symptoms. [7] Major depression is more severe, and lasts longer than sadness, which is a normal part of life. [2]
In particular, the effect size was very small for moderate depression but increased with severity, reaching "clinical significance" for very severe depression. [ 100 ] [ 101 ] These results were consistent with the earlier clinical studies in which only patients with severe depression benefited from either psychotherapy or treatment with an ...
Ketamine has been tested as a rapid-acting antidepressant [13] for treatment-resistant depression in bipolar disorder, and major depressive disorder. [14] Spravato, a nasal spray form of esketamine, was approved by the FDA in 2019 for use in treatment-resistant depression when combined with an oral antidepressant. [15] [16]