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If the chromosome is a submetacentric chromosome (One arm big and the other arm small) then the centromere divides each chromosome into two regions: the smaller one, which is the p region, and the bigger one, the q region. The sister chromatids will be distributed to each daughter cell at the end of the cell division.
In this diagram of a duplicated chromosome, (2) identifies the centromere—the region that joins the two sister chromatids, or each half of the chromosome. In prophase of mitosis, specialized regions on centromeres called kinetochores attach chromosomes to spindle fibers. The centromere links a pair of sister chromatids together during cell ...
Duplicated chromosome. (2) identifies the Monocentric centromere—the region that joins the two sister chromatids, or each half of the chromosome.In prophase of mitosis, specialized regions on centromeres called kinetochores attach chromosomes to spindle fibers.
During cell division, the identical copies (called a "sister chromatid pair") are joined at the region called the centromere (2). Once the paired sister chromatids have separated from one another (in the anaphase of mitosis ) each is known as a daughter chromosome.
Each chromatid has a special region, named the centromere, on top of which is assembled a proteic structure termed kinetochore, which is able to stabilize the microtubule plus end. Therefore, if by chance a microtubule exploring the center of the cell encounters a kinetochore, it may happen that the kinetochore will capture it, so that the ...
During mitosis, which occurs after the amount of DNA is doubled in each chromosome (while maintaining the same number of chromosomes) in S phase, two sister chromatids are held together by a centromere. Each chromatid has its own kinetochore, which face in opposite directions and attach to opposite poles of the mitotic spindle apparatus.
Centromere protein A, also known as CENPA, is a protein which in humans is encoded by the CENPA gene. [5] CENPA is a histone H3 variant which is the critical factor determining the kinetochore position(s) on each chromosome [ 6 ] in most eukaryotes including humans.
In addition to the centromere, one or more secondary constrictions can be observed in some chromosomes at metaphase. In humans they are usually associated with the short arm of an acrocentric chromosome, [1] such as in the chromosomes 13, 14, 15, 21, & 22.