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Cutaneous squamous-cell carcinoma is the second-most common cancer of the skin (after basal-cell carcinoma, but more common than melanoma). It usually occurs in areas exposed to the sun. Sunlight exposure and immunosuppression are risk factors for SCC of the skin, with chronic sun exposure being the strongest environmental risk factor. [26]
Squamous-cell carcinoma (SCC), also known as epidermoid carcinoma, comprises a number of different types of cancer that begin in squamous cells. [1] These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the lining of the respiratory and digestive tracts .
It is associated with a high lifetime risk of squamous cell carcinomas in skin. [1] It generally presents with scaly spots and small bumps particularly on the hands, feet, face, and neck; typically beginning in childhood or a young adult. [1] The bumps tend to be flat, grow in number, and then merge to form plaques. [1]
About 5.4 million basal and squamous cell cancers (the two most common types of skin cancer) are diagnosed each year in the U.S., and about 80% of those are basal cell cancers, the American Cancer ...
Conditions of or affecting the human integumentary system associated with increased risk of nonmelanoma skin cancer Condition Squamous-cell carcinoma Basal-cell carcinoma; Xeroderma pigmentosum + + Oculocutaneous albinism + + Epidermodysplasia verruciformis + Recessive dystrophic epidermolysis bullosa + Ferguson–Smith syndrome + Muir–Torre ...
These are called Marjolin's ulcers based on their appearance, and can develop into squamous-cell skin cancer. Ionizing radiation such as X-rays, environmental carcinogens, and artificial UV radiation (e.g. tanning beds). [30] It is believed that tanning beds are the cause of hundreds of thousands of basal and squamous-cell skin cancer. [33]
The rash often appears on the face near the hairline, then spreads down to the feet. Other symptoms to note : The rash is accompanied by flu-like symptoms, including high fever, cough, and runny nose.
The two main types of human skin are: glabrous skin, the hairless skin on the palms and soles (also referred to as the "palmoplantar" surfaces), and hair-bearing skin. [3] Within the latter type, the hairs occur in structures called pilosebaceous units , each with hair follicle , sebaceous gland , and associated arrector pili muscle. [ 4 ]