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Pituitary gland tumors are very common in the canine. A productive form arising from the anterior pituitary is the primary cause of Cushing's disease of dogs. This tumor causes excessive production of cortisol from the adrenal cortex which leads to the classic signs of alopecia (hair loss), polyuria (excessive urination), polydipsia (excessive water drinking), and a pot-bellied appearance of ...
A glioma is a type of primary tumor that starts in the glial cells of the brain or spinal cord.They are cancerous but some are extremely slow to develop. [2] [3] Gliomas comprise about 30 percent of all brain tumors and central nervous system tumours, and 80 percent of all malignant brain tumours.
Schematic block diagram of an adaptive design for a clinical trial [1] In an adaptive design of a clinical trial, the parameters and conduct of the trial for a candidate drug or vaccine may be changed based on an interim analysis. [2] [1] [3] Adaptive design typically involves advanced statistics to interpret a clinical trial endpoint. [1]
A pivotal clinical trial carried out in the early 1970s showed that among 303 GBM patients randomized to radiation or best medical therapy, those who received radiation had a median survival more than double those who did not. [79] Subsequent clinical research has attempted to build on the backbone of surgery followed by radiation.
The SADS also allows more flexibility than fully structured interviews: Interviewers can use their own words and rephrase questions, and some clinical judgment is used to score responses. There are three versions of the schedule, the regular SADS, the lifetime version (SADS-L) and a version for measuring the change in symptomology (SADS-C).
The Montreal Cognitive Assessment (MoCA) is a widely used screening assessment for detecting cognitive impairment. [1] It was created in 1996 by Ziad Nasreddine in Montreal, Quebec. It was validated in the setting of mild cognitive impairment (MCI), and has subsequently been adopted in numerous other clinical settings. This test consists of 30 ...
The DA2PPC vaccine protects against the debilitating and deadly disease canine distemper. This disease is a fatal viral illness that causes neurologic dysfunction, pneumonia, nonspecific systemic symptoms such as fever and fatigue, and weight loss, as well as upper respiratory symptoms and diarrhea, poor appetite, and vomiting. [4]
A drawing by Konrad Lorenz showing facial expressions of a dog. The grimace scale (GS), sometimes called the grimace score, is a method of assessing the occurrence or severity of pain experienced by non-human animals according to objective and blinded scoring of facial expressions, as is done routinely for the measurement of pain in non-verbal humans.