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Daratumumab, sold under the brand name Darzalex among others, is an anti-cancer monoclonal antibody medication. It binds to CD38 , [ 7 ] which is overexpressed in multiple myeloma cells. [ 8 ]
It was approved for use in the United States in May 2020. [2] [7] [8]Efficacy of daratumumab and hyaluronidase-fihji (monotherapy) was evaluated in the COLUMBA trial (NCT03277105), an open-label non-inferiority trial randomizing 263 participants to daratumumab and hyaluronidase-fihj and 259 to intravenous daratumumab (daratumumab IV). [2]
When used as drugs, the International Nonproprietary Names (INNs) end in -mab. The remaining syllables of the INNs, as well as the column Source , are explained in Nomenclature of monoclonal antibodies .
After daratumumab treatment, both patients showed stabilization of kidney function parameters and a steep decline in dd-cfDNA levels below the clinical threshold for rejection. Biopsies six months after treatment demonstrated complete histologic resolution of AMR activity in one patient and partial resolution in the other.
The BCG vaccine, mainly used to prevent tuberculosis, is also a standard treatment for some forms of bladder cancer. Last year, the U.S. Food and Drug Administration approved ImmunityBio's ...
CD38 has been used as a prognostic marker in leukemia. [31] Daratumumab (Darzalex) which targets CD38 has been used in treating multiple myeloma. [32] [33] The use of Daratumumab can interfere with pre-blood transfusion tests, as CD38 is weakly expressed on the surface of erythrocytes.
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