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It can increase the risk of serious cardiovascular events, such heart attack and stroke. Statins are a medication type that can help people at risk for atherosclerotic cardiovascular disease.
A new analysis re-evaluates statins and who should use them. Statins are widely used to help lower cholesterol. Using a new analysis, researchers found that millions of people may be taking ...
Impact of statins on cholesterol, heart disease risk Cheng-Han Chen, MD , of Saddleback Medical Center, CA, not involved in the study, explained that cholesterol in the body comes from two sources.
On average, statins can lower LDL cholesterol by 1.8 mmol/L (70 mg/dL), which translates into an estimated 60% decrease in the number of cardiac events (heart attack, sudden cardiac death) and a 17% reduced risk of stroke after long-term treatment. [36] A greater benefit is observed with high-intensity statin therapy. [37]
JUPITER was a randomized double-blind placebo-controlled study investigating the use of rosuvastatin in the primary prevention of cardiovascular disease.The trial focused on patients with normal low-density lipoprotein (LDL) cholesterol levels but increased levels of high-sensitivity C-reactive protein (hs-CRP).
Risk of heart attack and stroke. [2] Vincamine: 1987 Germany Hematologic toxicity. [3] Xenazoic acid: 1965 France Hepatotoxicity. [3] Ximelagatran (Exanta) 2006 Germany Hepatotoxicity [14] Zimelidine: 1983 Worldwide Risk of Guillain–Barré syndrome, hypersensitivity reaction, hepatotoxicity [3] [67] [68] banned worldwide. [69] Zomepirac: 1983 ...
A small increased risk of raised blood sugar levels and the development of type 2 diabetes have been reported with the use of statins. A 2010 published meta-analysis found for every 255 patients taking a statin for 4 years, one additional case of diabetes would occur whilst preventing 5.4 major coronary events. [27]
QRISK3 (the most recent version of QRISK) is a prediction algorithm for cardiovascular disease (CVD) that uses traditional risk factors (age, systolic blood pressure, smoking status and ratio of total serum cholesterol to high-density lipoprotein cholesterol) together with body mass index, ethnicity, measures of deprivation, family history, chronic kidney disease, rheumatoid arthritis, atrial ...