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Colchicine was a narrow therapeutic index drug that was implicated in numerous death leading to the FDA forcefully removing injectable colchicine from the US Market. [ 63 ] [ 64 ] At this time oral colchicine was being used to treat gout attacks.
Colchicine (Colcrys) for pericarditis: colchicine is indicated for the treatment and prevention of gout, though it is also generally considered first-line treatment for acute pericarditis, as well as preventing recurrent episodes. Although the exact mechanism of colchicine is not fully understood, its anti-inflammatory effect for pericarditis ...
ATC code M04 Antigout preparations is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. [1] [2] [3] Subgroup M04 is part of the anatomical group M Musculo-skeletal system. [4]
Colchicine, a drug for gout, interferes with the function of the structural protein tubulin, while digitalis, a drug still used in heart failure, inhibits the activity of the carrier molecule, Na-K-ATPase pump. The widest class of drugs act as ligands that bind to receptors that determine cellular effects.
While colchicine is not used to treat cancer in humans, it is commonly used to treat acute attacks of gout. [26] Colchicine is an anti-inflammatory drug that has been in continuous use for more than 3000 years. Colchicine is an oral drug, known to be used for treating acute gout and preventing acute attacks of familial Mediterranean fever (FMF).
Generally, drugs outlined within the ATC code M04 should be included in this category. Please see WP:PHARM:CAT for more information. Wikimedia Commons has media related to Antigout agents .
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Probenecid with colchicine is a combination medication used to treat gout. Brand names include ColBenemid, Col-Probenecid, and Proben-C. [1] References