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Today Gynatren is the only lactobacillus vaccine marketed for the treatment of non-specific bacterial vaginitis and trichomoniasis, and it is mostly only prescribed by a select few gynaecologists in the DACH countries and Hungary. In Germany the vaccine may be covered by health insurance upon individual deliberation of the attending gynaecologist.
Certain types of vaginitis may result in complications during pregnancy. [1] The three main causes are infections, specifically bacterial vaginosis, vaginal yeast infection, and trichomoniasis. [2] Other causes include allergies to substances such as spermicides or soaps or as a result of low estrogen levels during breast-feeding or after ...
[1] [2] Having trichomoniasis increases the risk of getting HIV/AIDS. [1] It may also cause complications during pregnancy. [1] Trichomoniasis is a sexually transmitted infection (STI) most often spread by vaginal, oral, or anal sex. [1] It can also spread through genital touching (manual sex). [1]
The 5-nitroimidazole drugs (metronidazole and tinidazole) are the mainstay of treatment for infection with Trichomonas vaginalis. Treatment for both the infected patient and the patient's sexual partner is recommended, even if asymptomatic. Therapy other than 5-nitroimidazole drugs is also an option, but cure rates are much lower. [25]
Trichomonas vaginalis from a vaginal swab. This is a heavy infection; there were probably thousands of trichomonads in the vagina. Alfred Francois Donné (1801–1878) was the first to describe a procedure to diagnose trichomoniasis through "the microscopic observation of motile protozoa in vaginal or cervical secretions" in 1836.
The treatment of abnormal vaginal microbiota populations with lactobacilli and estriol during pregnancy was found to restore the microbiota to a normal state. [4] During pregnancy, the vaginal microbiome can contribute and play an important role in spontaneous and preterm labor.
Fenticonazole is an imidazole antifungal drug, used locally as the nitrate in the treatment of vulvovaginal candidiasis. It is active against a range of organisms including dermatophyte pathogens, Malassezia furfur, and Candida albicans.
Trichomonas foetus is a parasite that resides in the urogenital tract of cattle and causes bovine trichomoniasis. Trichomoniasis is a sexually transmitted disease that causes infertility in heifers. Most infertility is caused by sudden embryonic death. [9] Various imidazoles have been used to treat infected bulls, but none are safe and effective.