Search results
Results From The WOW.Com Content Network
Multiple system atrophy is estimated to affect approximately 5 per 100,000 people. At autopsy, many patients diagnosed during life with Parkinson's disease are found actually to have MSA, suggesting that the actual incidence of MSA is higher than that estimate. [ 4 ]
The DNA repair function of alpha-synuclein appears to be compromised in Lewy body inclusion bearing neurons, and this may trigger cell death. Study of synucleinopathy mouse models of Parkinson's disease indicates that alpha-synuclein pathogenesis is associated with increased DNA damage and activation of the DNA damage response.
In multiple system atrophy, autonomic dysfunction appears earlier and is more severe, [39] and is accompanied by uncoordinated movements, while visual hallucinations and fluctuating cognition are less common than in DLB. [150] Urinary difficulty is one of the earliest symptoms with multiple system atrophy, and is often severe. [70]
They include multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). Dementia with Lewy bodies (DLB), may or may not be part of the PD spectrum, but it is increasingly recognized as the second-most common type of neurodegenerative dementia after Alzheimer's disease.
The hotcross bun sign is a radiologic sign observed on transverse T2-weighted magnetic resonance (MR) images of the brain, describing a cross-shaped (or cruciform) hyperintensity within the pons. This sign is most commonly associated with the cerebellar subtype of multiple system atrophy (MSA-c). [ 1 ]
Upper motor neuron lesions occur in the brain or the spinal cord as the result of stroke, multiple sclerosis, traumatic brain injury, cerebral palsy, atypical parkinsonisms, multiple system atrophy, and amyotrophic lateral sclerosis.
Nervous system: pupillary defect, exaggerated hippus, dizziness or lightheadedness. Other areas: hypoglycemia unawareness, genital impotence, sweat disturbances, sicca (dryness). Absence of signs of cerebellar dysfunction or parkinsonian symptoms as the presence of either would indicate the more serious disease of multiple system atrophy.
Cerebellar ataxia is a form of ataxia originating in the cerebellum. [1] Non-progressive congenital ataxia (NPCA) is a classical presentation of cerebral ataxias.. Cerebellar ataxia can occur as a result of many diseases and may present with symptoms of an inability to coordinate balance, gait, extremity and eye movements. [2]