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With further reports of the increased risk of kidney injury with prolonged and excessive phenacetin use, however, phenacetin was banned in several countries between the 1960s and 1980s. [20] As the use of phenacetin declined, so too did the prevalence of analgesic nephropathy as a cause of end-stage kidney disease.
Phenacetin (/ f ɪ ˈ n æ s ɪ t ɪ n / ⓘ; acetophenetidin, N-(4-ethoxyphenyl)acetamide [1]) is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887.
However, it became recognised that these medications were addictive, and Priscilla Kincaid-Smith found that the large doses of phenacetin ingested by habitual users were responsible for widespread kidney disease. [4] [5] The phenacetin was removed from Bex in 1975. [6] Bex has also been linked to kidney cancer. [7]
Kidney disease. CDC. 10 Signs You May Have Kidney Disease. National Kidney Foundation. Aging and kidney disease. National Kidney Foundation. Kidney Transplant Outcomes in Recipients Over the Age ...
The term "non-dialysis-dependent chronic kidney disease" (NDD-CKD) is a designation used to encompass the status of those persons with an established CKD who do not yet require the life-supporting treatments for kidney failure known as kidney replacement therapy (RRT, including maintenance dialysis or kidney transplantation).
This is especially true for Healthy life expectancy, the definition of which criteria may change over time, even within a country. For example, Canada is a country with a fairly high overall life expectancy at 81.63 years; however, this number decreases to 75.5 years for Indigenous people in the country. [4]
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