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Wellbutrin is effective at reducing the severity of depression symptoms for most people, but like other antidepressants, it doesn’t always start working right away.
Some people may need antidepressants for a relatively short period (like while grieving the loss of a loved one), or they might need medication long-term, if the depression is chronic.
The truth is, antidepressants don’t always work — at least, not all antidepressants work for everyone. In fact, it’s not uncommon for people to try multiple antidepressants before finding ...
Before the 1950s, opioids and amphetamines were commonly used as antidepressants. [ 266 ] [ 267 ] [ 196 ] Amphetamine has been described as the first antidepressant. [ 196 ] Use of opioids and amphetamines for depression was later restricted due to their addictive nature and side effects.
This delay can explain the reason why antidepressants do not have effect on depression immediately. This can also be the reason why the antidepressant mechanisms can be connected to the increasing neuro impulse flow from 5-HT neurons, where as the concentration of 5-HT increases at the axon terminal before SSRIs start to work properly.
However, there are differences between TCA related antidepressants and classical TCAs in terms of side effect profiles and withdrawal when compared to SSRIs. [67] There is evidence a prominent side-effect of antidepressants, emotional blunting, is confused with a symptom of depression itself. The cited study, according to Professor Linda Gask was:
In general, large-scale studies do tend to show that long-term use of antidepressants is associated with weight gain side effects. However, study data on escitalopram and weight changes is very ...
Mirtazapine, sold under the brand name Remeron among others, is an atypical tetracyclic antidepressant, and as such is used primarily to treat depression. [11] [12] Its effects may take up to four weeks but can also manifest as early as one to two weeks.